Iron overload in myelodysplastic syndromes
نویسندگان
چکیده
منابع مشابه
Iron overload in myelodysplastic syndromes: diagnosis and management.
Myelodysplastic syndrome (MDS) is composed of a diverse spectrum of hematopoietic stem cell malignancies characterized by ineffective blood cell production. Many MDS patients are dependent on red blood cell (RBC) transfusions for symptomatic management of refractory anemia. Iron overload ensues when the iron acquired from transfused RBCs exceeds body storage capacity, thereby raising the risk f...
متن کاملIron overload and chelation therapy in myelodysplastic syndromes.
Iron overload remains a concern in MDS patients especially those requiring recurrent blood transfusions. The consequence of iron overload may be more relevant in patients with low and intermediate-1 risk MDS who may survive long enough to experience such manifestations. It is a matter of debate whether this overload has time to yield organ damage, but it is quite evident that cellular damage an...
متن کاملIron overload in myelodysplastic syndromes: a Canadian consensus guideline.
In December 2005, 11 Canadian hematologists met to develop an evidence-based clinical practice guideline that would address the diagnosis, monitoring, management, and rationale for the treatment of transfusional iron overload in patients with myelodysplastic syndromes (MDS). This Expert Panel consisted of hematologists from across Canada, each with an active practice in a major population centr...
متن کاملOverview of guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload
Between 2002 and 2008, a number of consensus statements and guidelines were developed by various groups around the world to educate healthcare professionals on the treatment of myelodysplastic syndromes (MDS), including the management of transfusional iron overload with iron chelation therapy. Guidelines have been developed by The Italian Society of Hematology, The UK MDS Guidelines Group, The ...
متن کاملThe role of magnetic resonance imaging in the evaluation of transfusional iron overload in myelodysplastic syndromes
Myelodysplastic syndromes represent a group of heterogeneous hematopoietic neoplasms derived from an abnormal multipotent progenitor cell, characterized by a hyperproliferative bone marrow, dysplasia of the cellular hemopoietic elements and ineffective erythropoiesis. Anemia is a common finding in myelodysplastic syndrome patients, and blood transfusions are the only therapeutic option in appro...
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ژورنال
عنوان ژورنال: Expert Review of Hematology
سال: 2009
ISSN: 1747-4086,1747-4094
DOI: 10.1586/ehm.09.23